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Research papers by Chulhee Choi
Chulhee Choi, MD, PhD

Professor
Chair, Optical Bioimaging Center
Cell Signaling and BioImaging Laboratory
Department of Bio and Brain Engineering, KAIST
291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Korea
Tel: +82-42-350-4321/8552, Fax: +82-42-350-4380
E-mail: cchoi@kaist.ac.kr

8/99 PhD Degree, Microbiology, Yonsei University College of Medicine, Seoul, Korea,
Mentor: In-hong Choi, MD, PhD
3/95 ~ 2/99 Residency, Neurology, Yonsei University Medical Center
2/97 Masters Degree, Neurology, Yonsei University College of Medicine
3/91 ~ 2/92 Internship, Internal Medicine, Yonsei University Medical Center, Korea
2/91 MD Degree, Yonsei University College of Medicine, Seoul, Korea

03/12 ~ present Professor: Department of Bio and Brain Engineering, KAIST
10/09 ~ present Chair: Optical Bioimaging Center, KAIST
4/07 ~ present Member: KI for the BioCentury, KAIST
4/06 ~ present Adjunctive professor: Graduate School of Medical Science and Engineering, KAIST
4/06 ~ present Chair: BK21 Center for Bio-Medical Information Technology, KAIST
3/05 ~ present Associate Professor: Department of Bio and Brain Engineering, KAIST
9/02 ~ 2/05 Assistant Professor: Division of Molecular Life Sciences, Ewha Womans University, Seoul, Korea
10/01 ~ 12/03 Research Instructor: Department of Cell Biology, UAB
4/99 ~ 9/01 Postdoctoral Fellow: Department of Cell Biology, University of Alabama at Birmingham (UAB), Mentor: Etty N. Benveniste, PhD
Active Member of American Association of Cancer Research (AACR), since 2009
Regular Member of The Korean Cancer Association, since 2009
Regular Member of the Pharmaceutical Society of Korea, since 2009
Regular Member of Korean Association of Neurology, since 1999
Regular Member of Korean Medical Association, since 1991
Regular Member of Korean Society for Molecular and Cellular Biology (KSMCB), since 2003
Regular Member of Korean Society for Cell Biology (KSCB), since 2003
Regular Member of Korean Society for Brain and Neural Science (KSBNS), since 2003
Corresponding Junior Member of American Academy of Neurology (AAN), 2000-2002
Regular Member of American Association of Immunologists (AAI), 2001-2003
Regular Member of American Society for Microbiology (ASM), 2001-2003
Best paper award from Korean Cancer Association for ¡°Caspase-dependent generation of reactive oxygen species in human astrocytoma cells confers tumor resistance to TRAIL-mediated apoptosis¡±, 6/17/2011 (at 37th Annual Conference, Seoul, Korea)
Best lecturerer award from Department of Bio and Brain Engineering, KAIST, Fall Semester/2010, Spring semester/2006, Fall semester/2005
2010 S&T award (Excellence in biomedical research) from Korea Federation of Science and Technology Societies, 7/6/10 (at 2010 Korea S&T annual meeting, Daegu)
2010 Korea Cancer Research Foundation Award (Excellence in basic cancer research) for ¡°Proapoptotic Ginsenosides Compound K and Rh2 Enhance Fas-induced Cell Death of Human Astrocytoma Cells through Distinct Apoptotic Signaling Pathways¡± from Korean Cancer Association, 6/11/10 (at the 36th Annual Meeting, Lotte Hotel, Seoul)
2009 Health Industry Technology Award (Excellence in Biomedical Research) for ¡°Development of Near Infrared Fluorescence Imaging Technology for Measurement of Peripheral Tissue Perfusion¡± from Ministry for Health, Welfare & Family Affairs, Republic of Korea, 12/08/09 (at the HITEK 2009, Coex, Seoul)
2009 Technology Innovation Award (Excellence in Technology Innovation), KAIST
Minister Prize for Excellence in University-Industry Cooperation from Ministry of Education, Science and Technology, Republic of Korea, 11/5/09 (at the 2009 UIC EXPO University-Industry Cooperation Center, Ilsan, Korea)
Bumsuk Award (Best academic achievement) from Eulji Foundation, 2004/2005/2006/2009
John R. Durant Award (Junior faculty category) for Excellence in Cancer Research from the Comprehensive Cancer Center of University of Alabama at Birmingham, 2001/200.
AAI Junior Faculty Travel Award for AAI Annual Meeting from the American Association of Immunologists, Apr 22, 2002
S. Weir Mitchell Award from the American Academy of Neurology, May 11, 2001
John R. Durant Award (Post-doctoral category) for Excellence in Cancer Research from the Comprehensive Cancer Center of University of Alabama at Birmingham, Oct 25, 1999
Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (2009-0080280), Development of tumor vessel-specific gene analysis system based on in vivo-mimetic tumor models. $100,000 per year. 5/1/09-2/29/15
Fundamental Technology Developmenet grant (2011-0019697) as a co-PI (PI: Prof. Kihwan Kwon, Ewha Womans University) funded by the National Research Foundation (NRF) of Kroea. Development of technology to prevent post-angioplastic restenosis. $150,000 per year. 6/12011~5/31/2014
Optical Bioimaging Center funded by Vieworks Corporation: $100,000/year. 11/1/2009~10/31/2014
Fundamental Technology Developmenet grant (2010-00300001) funded by the National Research Foundation (NRF) of Kroea. Validation study of MKP-1 as a novel target of malignant cancer and discovery of target genes through associated gene network analysis. $150,000 per year. 12/1/2010~10/31/2013
Brain Korea 21, Ministry of Education, Science and Technology (Republic of Korea), Bio-Medical Information Technology. $100,000 per year. 4/01/06~3/31/13
Brain Research Center of the 21st Century Frontier Research Program (2009K001282) funded by the Ministry of Education, Science and Technology, Development of in vivo imaging technique and system for analysis of neurovascular function. $150,000 per year. 4/1/2009~3/31/2013
Korea Health 21 R&D Project (A091258), as a Co-PI (Collaboration with VieWorks) Ministry of Health & Welfare (Republic of Korea), Development of novel medical device for evaluation of endothelial function. $100,000 per year. 5/01/09-4/30/11
2. IT R&D program of MKE/IITA (2008-F-021-01) as a Co-PI (PI: Prof. Jongchul Ye, KAIST), Development of high speed terahertz/NIR spectroscopic endoscopy using THz frequency comb technology. $35,000 per year. 3/01/08~2/28/11
Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (2009-0080280), Development of tumor vessel-specific gene analysis system based on in vivo-mimetic tumor models. $100,000 per year. 5/1/09-2/29/12
Korea Health 21 R&D Project (A091258), as a Co-PI (Collaboration with VieWorks) Ministry of Health & Welfare (Republic of Korea), Development of novel medical device for evaluation of endothelial function. $100,000 per year. 5/01/09-4/30/11
IT R&D program of MKE/IITA (2008-F-021-01) as a Co-PI (PI: Prof. Jongchul Ye, KAIST), Development of high speed terahertz/NIR spectroscopic endoscopy using THz frequency comb technology. $35,000 per year. 3/01/08~2/28/11
Korea Science and Engineering Foundation (R01-2007-000-20928-0) as a Co-PI (PI: Prof. Yoonsun Song, Sookmyung University, Korea), Ministry of Education, Science and Technology (MEST, Republic of Korea), Role of angiogenesis in neuronal damage and function after stroke. $35,000 per year. 9/01/07~8/30/10
Korea Health 21 R&D Project (A084215), Ministry of Health & Welfare, Multiparametirc vascular imaging of tumor vasculature. $50,000 per year. 10/01/08-9/30/10
High risk high return project from KAIST, Development of non-invasive early diagnosis techniques for chronic neurodegenerative diseases. $30,000. 1/01/08~12/31/08
Korea Research Foundation (KFR-2006-312-E00183), Role of the Ubiquitin Pathway on Tumor Necrosis Factor Signaling. $40,000 per year. 7/01/06~6/30/08
Korea Health 21 R&D Project (A060687), Ministry of Health & Welfare (Republic of Korea), Vascular Remodeling using TRAIL. $50,000 per year. 5/01/06-4/30/08
Korea Health 21 R&D Project (A050419), Ministry of Health & Welfare (Republic of Korea), Modulation of mitochondrial activation for neuroprotection from ischemic brain injury. $50,000 per year. 5/01/05-4/30/07
Korea Health 21 R&D Project (03-PJ1-PG3-21300-0009), Ministry of Health & Welfare (Republic of Korea), Effects of proteosome inhibitors on TNF-a and IL-1b signaling pathways in human astrocytes: Implication in Alzheimer¡¯s Disease and Aging. $30,000. 5/01/03-4/30/05
Korea Health 21 R&D Project (02-PJ10-PG4-PT02-0043), Ministry of Health & Welfare (Republic of Korea), Color-coded antibody bead kit for diagnosis of the neurodegenerative disorders. $100,000 per year. 12/01/02-4/30/07
Ginseng Grant from Korea Food Research Institute, $40,000 per year. 3/1/04-2/28/07
Pilot Research Grant from American Brain Tumor Association, Synergistic effect of proteasome inhibitors on TRAIL-induced tumor cytotoxicity. $50,000. 7/1/02-6/30/03
Junior Faculty Development Grant, Ewha Womans University, The role of the ubiquitin/proteasome pathway on interleukin-1b signaling in human astrocytes. $20,000. 10/1/02-9/30/03
Junior Faculty Development Grant, UAB Comprehensive Cancer Center, The role of the ubiquitin/proteasome pathway on death ligand-mediated signaling. $25,000. 3/1/02-2/28/03
VieWorks Corporation (2008) Apparatus for Measuring the Perfusion Rate of Legs. 3% of SALES with initial $10,000 royalty.
Choi C. Cell Biology for Non-Biologist. 1st edition. PubPle. 2012
Choi C. Bloody Biotechnology, Red Biotechnology. 1st edition. PubPle. 2012
Chong K, Ku T, Choi K, Choi M, Yoon J, Choi C. Current Optical Imaging Techniques for Brain Tumor Research: Application of in vivo Laser Scanning Microscopy Imaging with a Cranial Window System, Diagnostic Techniques and Surgical Management of Brain Tumors, Ana Lucia Abujamra (Ed.), (ISBN: 978-953-307-589-1) 2011, pp155-172
Choi K, Lee J, Choi C. Role of ubiquitination on proinflammatory cytokine signaling in the central nervous system. In ¡°Role of the ubiquitin-proteasome pathway in the central nervous sytems¡± 2nd edition by Worzic, 2010, In Press
Selective delivery of nanomedicine through vascular barrier using ultrashort pulsed lasers. (Apr 18, 2012, SNU-KAIST-ETHZ-EPFL Joint Symposium on engineering for biomedical applications, Seoul National University, Korea)
Biophotonics beyond bioimaging: novel biomodulation using femtosecond pulsed LASERs. (Oct 30, 2011, 2nd Pacific symposium on vascular biology, Jeju Island, Korea)
Novel noninvasive molecular delivery into the brain by optical permeabilization of blood brain barrier. (July 1, 2011, SIRIC International Symposium, Seoul, Korea)
Beyond Bioimaging: application of femtosecond laser in biomodulation. (May 19, 2010, Intrernational conference on Bioimaging and Cell dynamics, GIST, Korea)
Future medical technology at post-ome era. (May 28, 2008, KHUPO, Jeju, Korea)
Quantitative and functional imaging of perfusion in peripheral tissue. (Nov, 2007, 1st Pacific symposium of vascular biology, Jeju Island, Korea)
Role of reactive oxygen species on death receptor signaling in human malignant astrocytoma cells. (Oct 20, 2007, APSN, Dalian, China)
TRAIL induces caspase-dependent Interleukin-8 expression by human astroglioma cells. (May 11, 2001, American Academy of Neurology Annunal Meeting, Philadelphia, PA)
Chong K, Choi K, Cha J, Ku T, Yoon J, Han EC, Lee J, Park JH, Choi C. Coloring brain tumor with multi-potent nanoscale drug delivery system. (Apr 18, 2012, SNU-KAIST-ETHZ-EPFL Joint Symposium on engineering for biomedical applications, Seoul National University, Korea)
Ku T,Choi C. In silico modeling and simulation for calculation of cerebral blood flow. (Apr 18, 2012, SNU-KAIST-ETHZ-EPFL Joint Symposium on engineering for biomedical applications, Seoul National University, Korea)
Yoon J, Ku T, Chong K, Ryu S-W, Choi C. Optical modulation of astrocyte network using ultrashort pulsed laser. (Jan 2012, Photonics West, San Francisco, CA, USA)
Song S, Lee J, Chang S, Choi K, Park J, Choi C. Phenotypic modulation of vascular smooth muscle cells by micropatterned substrate culture. (Oct 2011, The Second Pacific Symposium on Vascular Biology, Jeju, Korea)
Lee J, Lee J, Yu H, Choi K, Choi C. Differential dependency of human cancer cells on VEGF-mediated autocrinegrowth and survival (Sep, 2011, AACR special meeting on frontiers on basic cancer research, San Francisco, CA)
Park J, Kang W, Ryu S, Kim W, Chang D, Shin E, Choi C. Hepatitis C virus enhances tumor necrosis factor-alpha induced cell death via suppression of nuclear factor-kappaB activation (September, 2011, 18th international symposium on hepatitis C virus and related viruses, Seattle, Washington, USA)
Choi M, Choi C. Non-invasive optical modulation of local vascular permeability (Jan 2011, Photonics West, San Francisco, CA, USA)
Yoon J, Choi M, Choi C. Optical control of urination in neurogenic bladder using femtosecond-pulsed laser (Jan 2011, Photonics West, San Francisco, CA, USA)
Choi M, Ku T, Chong K, Yoon J, Choi C. Noninvasive optical interrogation of neurovascular coupling (Aug 2010, Gordon research conference on brain energy metabolism and blood flow, Andover, NH, USA)
Ku T, Chong K, Choi C. Quantitative measurement of cerebral blood flow using time-series analysis of indocyanine green molecular dynamics imaging in mice (Aug 2010, Gordon research conference on brain energy metabolism and blood flow, Andover, NH, USA)
Choi K, Ryu SW, Song S, Choi H, Choi C. Involvement of PKCd and NOX4 in Reactive Oxygen Species-Mediated Tumor Resistance to TRAIL-induced Apoptosis. (April 2010, American Association for Cancer Research 101st Annual meeting, Washington, D.C., USA)
Choi K, Choi C. Involvement of PKCd and NOX4 in reactive oxygen species-mediated tumor resistance to TRAIL-induced cell death (Feb 2010, AACR special conference on cell death mechanisms and cancer therapy, San Diego, CA, USA)
Park J, Choi C. Smad-dependent expression of MKP1 contributes tumor resistance to death receptor-mediated cell death (Feb 2010, AACR special conference on cell death mechanisms and cancer therapy, Keystone, CO, USA)
Choi K, Choi C. Involvement of PKCd and NOX4 in reactive oxygen species-mediated tumor resistance to TRAIL-induced cell death (Feb 2010, AACR special conference on cell death mechanisms and cancer therapy, San Diego, CA, USA)
Yoon J, Choi M, Choi C. Optical Modulation of Smooth Muscle Cell Contraction (Jan 2010, Photonics West, San Francisco, CA)
Choi M, Yoon J, Choi C. Label-free Optical Control Of Arterial Contraction (Jan 2010, Photonics West, San Francisco, CA)
Kang Y, Lee J, Kwon K, Choi C. Assessment of peripheral tissue perfusion by optical dynamic fluorescence imaging and nonlinear regression modeling (Jan 2010, Photonics West, San Francisco, CA)
Ku T, Lee J, Choi C. Cerebral blood flow imaging using time-series analysis of indocyanine green molecular dynamics in mice (Jan 2010, Photonics West, San Francisco, CA)
Yarimaga O, Song S, Choi C, Choi YK. Study of surface morphology control for a cell-implant onto an all-in-one chip. The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS), 2009, pp.201-203, Jeju, Korea, Nov. 1-5,
Choi K, Lee K, Choi C. Inhibitory effect of pirfenidone on TGFb-induced epithelial-mesenchymal transition of retinal epithelial cells (Jan 2009, Keystone Symposium on Fibrosis, Keystone, CO)
Choi M, Jeong T, Choi K, Choi C. Dynamic fluorescence imaging for multiparametric measurement of tumor vasculature (Jan 2009, Keystone Symposium on Tumor angiogenesis and lymphangiogenesis, Big Sky, MT)
Choi M, Jeong T, Choi K, Choi C. Dynamic fluorescence imaging for multiparametric measurement of tumor vasculature (Jan 2009, Photonics West, CA)
Choi K, Lee J, Choi C. Differential function of ubiquitination in proinflammatory cytokine signaling (Jan 2008, AACR Special Conference on Ubiquitin and Cancer: from molecular targets and mechanisms to the clinic, San Diego, CA)
Kang Y, Choi M, Lee J, Koh GY, Kwon K, Choi C. Quantitative and functional imaging of peripheral tissue perfusion using spatiotemporal molecular dynamics (Nov 2007, The First Pacific Symposium on Angiogenesis and Lymphangiogenesis, Jeju Island, Korea)
Song S, Han YH, Choi C. Effect of HDAC inhibitor-mediated downregulation of Trx I on vascular smooth muscle cells (Jul 2007, 32nd FEBS Congress, Vienna, Austria)
Kim J, Choi K, Ryu J, Ku T, Lee J, Choi C. JNK-involved activation of mitochondria in oxidative stress-induced necrosis of neuronal cells (Apr 2007, Keystone symposia on Apoptotic and non-apoptotic cell death pathways, Monterey, CA)
Park J, Song S, Choi C. Elucidation of p20¡¯s role in caspase-3 activation mechanism by using computational simulation (Mar 2007, Cold Spring Harbor Laboratory Conference on Computational Cell Biology, Cold Spring, NY)
Lee J, Choi C. Delineating the role of ubiquitin and proteasome complex on NF-kB activation pathway by a computational modeling approach. (Mar 2007, Cold Spring Harbor Laboratory Conference on Computational Cell Biology, Cold Spring, NY)
Kang Y, Choi M, Lee J, Choi C. Near Infrared ICG Fluorescence for Deep Tissue Perfusion Imaging. (Sep 2006, International conference on Bioengineering and Nanotechnology, Santa Barbara, CA)
Choi C. Role of Reactive Oxygen Species on TRAIL-Mediated Apoptosis (Oct 2003, iSBTc Annual Meeting, Bethesda, MA)
Choi C,, Benveniste EN. Role of the proteasome pathway on TRAIL-mediated apoptosis (Apr 2002, FASEB Annual Meeting, New Orleans, LA)
Choi C, Benveniste EN. Role of the ubiquitin/proteasome pathway on TRAIL-mediated signaling (Feb 2002, AACR Special Meeting on Apoptosis, Waikoloa, HI)
Choi C, Benveniste EN. Differential roles of caspases in Fas and DR5-mediated apoptosis and IL-8 production in human glioma cells (Apr 2001, FASEB Annual Meeting, Orlando, FL)
Choi C, Benveniste EN. Proinflammatory signals through TNF receptor family receptors (Nov 2000, Annual Neuroscience Meeting, New Orleans, LA)
Choi C, G. Y. Gillespie, Benveniste EN. Fas-induced Interleukin-8 in human malignant astrogliomas (Oct 2000, AACR Special Meeting on Angiogenesis and Cancer, Traverse city, MI)
Choi C, Xu X, Benveniste EN. Differential activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase is required for Fas-induced expression of chemokines and cytokines in human astroglioma cells (Feb 2000, AACR Special Meeting on Programmed Cell Death, Reno, NV)
Choi C, Benveniste EN. Regulation of death molecules by interferon-gamma in human astroglioma cell lines. (Sep 1999, Cold Spring Harbor Meeting on Programmed Cell Death, Cold Spring Harbor, NY)
Choi C, Choi IH. Expression of FasL and Fas in astrocytoma cell lines and cultures of human astrocytes. (Jul 1998, FASEB Summer Research Conference on Neural-Immune Interactions, Wilsonville, OR)
Choi C, Choi IH. Fas and Fas ligand expression in human astrocytes. (Jan 1998, AACR Special conference on Molecular mechanisms of apoptosis regulation, Palm Springs, CA)
Choi C, Sohn YH, Kim JS. Effects of long-term levodopa therapy on depression in Parkinson¡¯s disease. (Mar 1997, 11th International Conferences on Parkinson¡¯s Disease, London)
Choi C, Choi IH, Sunwoo IN. Increased T cell subsets in peripheral blood mononuclear cells with myasthenic patients. (Aug 1996, 9th Asian Oceanian Conference of Neurology, Seoul, Korea)